I wear a tie daily (yes, sometimes on weekends too) and own about 40. I could pare down a little, I guess, but I've looked at which ones I would get rid of, and even my least-worn ties get some wear. I bought a second tie hanger recently so I can at least keep my dressier silk ties and my more casual wool/knit/etc ties separated for easier access.
I am with @hornsup84 in that during a move/relocation last year, I threw away ~20 ties that were decent in terms of design but not special or high quality, or just didn't get any wear. I have added a few select high quality ties since and although I have overall less ties, I get more use out of them and enjoy wearing most of them.
I wear a tie typically once a week plus special occasions. I have probably 50-60 total. The wife has said that if a new tie comes into the house, one must leave the house. She's almost at that point about my shoes too but she has more shoes than I do by a fair amount so I still have leeway there.